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  • 8-0004.html0004.html04.htmll" uage_switchge_switch_switchitchchse-basket">e-basket">t-4'>iv> ogue"> gue"> ntrols"> trols"> h-disable">disable">sable">ble">manage.htmlnage.htmlge.htmll" utab_anchorab_anchor_anchorлениеениениеиееh-disable">disable">le">">pann b_adisabledadisabledisabledy reportsreportstsiv> v>/div>div>/li> r-sengine">n-to-book">to-book">-book">ook">9V0038.html0038.html38.htmlНТИБАКТЕРИАЛЬНЫЕ ЛЕКАРСТВЕННЫЕ СРЕДСТВАТИБАКТЕРИАЛЬНЫЕ ЛЕКАРСТВЕННЫЕ СРЕДСТВАИБАКТЕРИАЛЬНЫЕ ЛЕКАРСТВЕННЫЕ СРЕДСТВАБАКТЕРИАЛЬНЫЕ ЛЕКАРСТВЕННЫЕ СРЕДСТВАННЫЕ СРЕДСТВАtents">Table of contents
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    ЛЕКАРСТВЕННЫЕ ВЗАИМОДЕЙСТВИЯ
    ПРИМЕНЕНИЕ В ОСОБЫХ СИТУАЦИЯХ
    Раздел 4 / 14
    Страница 1 / 8

    МАКРОЛИДЫ

    Структурную основу макролидов составляет макроциклическое лактонное кольцо. В зависимости от числа атомов углерода в кольце макролиды подразделяют на 14-членные (кларитромицин, рокситромицин, эритромицин), 15-членные (азитромицин) и 16-членные (джозамицин, мидекамицин, спирамицин) (табл. 20-12). Основное клиническое значение имеет активность в отношении грамположительных кокков и внутриклеточных возбудителей (микоплазмы, хламидии, легионеллы, кампилобактерии).

    Таблица 20-12. Классификация макролидов

    Макролиды

     

    14-членные

     

    15-членные (азалиды)

     

    16-членные

     

    Природные

     

    Эритромицин

     

    -

     

    Спирамицин

     

    Джозамицин

     

    Мидекамицин

     

    Полусинтетические

     

    Кларитромицин

     

    Азитромицин

     

    Мидекамицина ацетат

     

    Рокситромицин

     

    -

     

    -