18. TYPICAL FORMS OF PATHOLOGY OF HEMOSTASIS

Questions to prepare for classes and examination

•  The system of hemostasis: components and their function.

•  Typical forms of pathology of the hemostatic system.

•  Thrombotic syndrome: its main causes, mechanisms of development, manifestations and consequences.

•  Hemorrhagic syndrome: causes, mechanisms of development, manifestations and consequences.

•  Causes and mechanisms of thrombocytopenia and thrombocytopathia.

•  Hemophylias and von Willebrand's disease.

•  Thrombo-hemorrhagic conditions. The syndrome of disseminated intravascular coagulation: stages, mechanisms of development, manifestations and consequences.

•  Laboratory parameters used to characterize hemostatic disorders: bleeding time, prothrombin time, partial thromboplastin time.

N 80

A 62-year-old patient was admitted to hospital with a diagnosis of myocardial infarction of the left ventricle and ischemic stroke associated with systemic atherosclerosis. On the next day his state was aggravated by the development of thromboembolism of the left popleteal artery and acute renal insufficiency with signs of uremia. On the third day of his stay in the hospital the patient's condition was complicated by the emergence of multiple subcutaneous hemorrhages and gastrointestinal bleeding. Blood tests showed marked thrombocytopenia, a considerable decrease in fibrinogen and prothrombin levels, a increased concentration of heparin and fibrin split products, and the enhancement of the blood fibrinolytic activity.