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Drugs are reabsorbed mainly by simple diffusion. This mainly concerns lipophilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH isan class="">The elimination of substances greatly depends on their reabsorption in renal tubules. Drugs are reabsorbed mainly by simple diffusion. This mainly concerns lipophilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH isreabsorption in renal tubules. Drugs are reabsorbed mainly by simple diffusion. This mainly concerns lipophilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH isabsorption in renal tubules. Drugs are reabsorbed mainly by simple diffusion. This mainly concerns lipophilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH issorption in renal tubules. Drugs are reabsorbed mainly by simple diffusion. This mainly concerns lipophilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH isrption in renal tubules. Drugs are reabsorbed mainly by simple diffusion. This mainly concerns lipophilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH ison in renal tubules. Drugs are reabsorbed mainly by simple diffusion. 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This mainly concerns lipophilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH isnal tubules. Drugs are reabsorbed mainly by simple diffusion. This mainly concerns lipophilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH isl tubules. Drugs are reabsorbed mainly by simple diffusion. This mainly concerns lipophilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH isoncerns lipophilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH iscerns lipophilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. 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Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH isphilic non-polar compounds, easily penetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH isnetrating through biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). 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When urine pH isrough biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH isugh biologic membranes. Polar compounds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH isds are poorly reabsorbed from the renal tubules. That is why elimination of weak acids and bases greatly depends on urine pH. Thus, when urine pH is alkaline, there is an increase in the elimination of acidic compounds (for example, salicylic acid, phenobarbital). When urine pH is are poorly reabsorbed from the renal tubules. 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#c0c0c0;cursor:hand;">popup_image(doc,ISBN9785970438831-0008,POPUP-Xz17-pic_0027.jpg,911,566)');}return false;}" style="padding:3 3 3 3px;border:1px dotted #c0c0c0;cursor:hand;">pup_image(doc,ISBN9785970438831-0008,POPUP-Xz17-pic_0027.jpg,911,566)');}return false;}" style="padding:3 3 3 3px;border:1px dotted #c0c0c0;cursor:hand;">)');}return false;}" style="padding:3 3 3 3px;border:1px dotted #c0c0c0;cursor:hand;">);}return false;}" style="padding:3 3 3 3px;border:1px dotted #c0c0c0;cursor:hand;">}return false;}" style="padding:3 3 3 3px;border:1px dotted #c0c0c0;cursor:hand;">urn false;}" style="padding:3 3 3 3px;border:1px dotted #c0c0c0;cursor:hand;">n false;}" style="padding:3 3 3 3px;border:1px dotted #c0c0c0;cursor:hand;">false;}" style="padding:3 3 3 3px;border:1px dotted #c0c0c0;cursor:hand;">1px dotted #c0c0c0;cursor:hand;">x dotted #c0c0c0;cursor:hand;">dotted #c0c0c0;cursor:hand;"> #c0c0c0;cursor:hand;">c0c0c0;cursor:hand;">c0c0;cursor:hand;">xtspan class="">Fig. II.12. Principles of renal excretion.ion of the mentioned compounds which prevents their reabsorption from the renal tubules.n of the mentioned compounds which prevents their reabsorption from the renal tubules.of the mentioned compounds which prevents their reabsorption from the renal tubules. the mentioned compounds which prevents their reabsorption from the renal tubules.mentioned compounds which prevents their reabsorption from the renal tubules.ntioned compounds which prevents their reabsorption from the renal tubules.ioned compounds which prevents their reabsorption from the renal tubules.s substances (amino acids, glucose, uric acid).substances (amino acids, glucose, uric acid).bstances (amino acids, glucose, uric acid).tances (amino acids, glucose, uric acid).es (amino acids, glucose, uric acid). (amino acids, glucose, uric acid).ino acids, glucose, uric acid).o acids, glucose, uric acid).acids, glucose, uric acid).asss=txtt"nt mechanisms of the elimination of a number of drugs (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13). mechanisms of the elimination of a number of drugs (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).echanisms of the elimination of a number of drugs (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).sms of the elimination of a number of drugs (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).s of the elimination of a number of drugs (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).of the elimination of a number of drugs (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).er of drugs (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13). of drugs (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).f drugs (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).drugs (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).ugs (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).s (tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).(tetracyclines, penicillins, phenytoin, colchicine, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).e, other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13). other) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).er) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).) and especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).d especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).especially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).pecially products of their transformation is their transfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).sfer with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).er with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13). with bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).h bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).bile into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).le into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).e into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).into the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).to the intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13). intestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).ntestine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).estine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).stine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).ine. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).e. A certain proportion of the drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).e drug is then eliminated with faeces, and the rest is reabsorbed. The cycle continues on, with the compound then again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).en again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13). again being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).in being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13). being eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13). eliminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).liminated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).minated into the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).o the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).the intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).e intestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).ntestine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).estine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).tine and so on (so-called hepato-intestinal circulation or hepatic recirculation; Fig. II.13).to-intestinal circulation or hepatic recirculation; Fig. II.13).-intestinal circulation or hepatic recirculation; Fig. II.13).ntestinal circulation or hepatic recirculation; Fig. II.13).estinal circulation or hepatic recirculation; Fig. II.13).inal circulation or hepatic recirculation; Fig. II.13).al circulation or hepatic recirculation; Fig. II.13).tic recirculation; Fig. II.13).c recirculation; Fig. II.13).recirculation; Fig. II.13).irculation; Fig. II.13).culation; Fig. II.13).lation; Fig. II.13).tion; Fig. II.13).on; Fig. II.13).g. 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