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3. BIOTRANSFORMATION OF DRUGS IN THE BODY

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Table of contents

I. INTRODUCTION

1. SUBJECT AND AIMS OF PHARMACOLOGY. ITS POSITION AMONG OTHER MEDICAL DISCIPLINES. MAIN STAGES OF PHARMACOLOGY DEVELOPMENT

2. CREATION OF NEW DRUGS

3. MAIN SECTIONS OF PHARMACOLOGY. PRINCIPLES OF CLASSIFICATION OF DRUGS

II. GENERAL PHARMACOLOGY

1. DRUG ADMINISTRATION ROUTES. ABSORPTION

2. DRUG DISTRIBUTION IN THE BODY. BIOLOGICAL BARRIERS. STORAGE

3. BIOTRANSFORMATION OF DRUGS IN THE BODY

4. ROUTES OF DRUG ELIMINATION FROM THE BODY

5. LOCAL AND SYSTEMIC EFFECTS OF THE DRUGS. DIRECT AND REFLEX EFFECTS.

LOCALIZATION AND MECHANISM OF ACTION. DRUG «TARGETS».

REVERSIBLE AND IRREVERSIBLE ACTIONS. SELECTIVE ACTION

6. DEPENDENCE OF PHARMACOTHERAPEUTIC ACTION ON DRUG PROPERTIES AND PATTERN OF USE

7. IMPORTANCE OF INDIVIDUAL CHARACTERISTICS OF THE HUMAN BODY AND ITS STATE FOR THE MANIFESTATION OF THE DRUG EFFECT

8. MAIN TYPES OF DRUG TREATMENT

9. PRINCIPAL AND ADVERSE EFFECT. ALLERGIC REACTIONS. IDIOSYNCRASY. TOXIC EFFECTS

10. GENERAL PRINCIPLES OF THE TREATMENT OF ACUTE DRUG POISONING 3

III. SPECIAL PHARMACOLOGY

A. DRUGS AFFECTING AFFERENT INNERVATION (CHAPTERS 1, 2)

CHAPTER 1. DRUGS DECREASING SENSITIVITY OF AFFERENT NERVE ENDINGS OR PREVENTING THEIR EXCITATION +

CHAPTER 2. DRUGS STIMULATING SENSORY NERVE ENDINGS +

B. DRUGS AFFECTING EFFERENT INNERVATION

CHAPTER 3. DRUGS AFFECTING CHOLINERGIC SYNAPSES +

CHAPTER 4. DRUGS AFFECTING ADRENERGIC SYNAPSES +

C. DRUGS REGULATING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM (CHAPTERS 5-12)

CHAPTER 5. GENERAL ANESTHETICS +

CHAPTER 6. ETHYL ALCOHOL

CHAPTER 7. HYPNOTICS +

CHAPTER 8. PAIN-RELIEVING DRUGS (ANALGESICS)+

CHAPTER 9. ANTIEPILEPTIC DRUGS

CHAPTER 10. ANTIPARKINSONIAN DRUGS

CHAPTER 11. PSYCHOTROPIC DRUGS +

CHAPTER 12. ANALEPTICS

D. DRUGS REGULATING FUNCTIONS OF MAJOR ORGANS AND THEIR SYSTEMS

CHAPTER 13. DRUGS AFFECTING THE RESPIRATORY SYSTEM +

CHAPTER 14. DRUGS AFFECTING THE CARDIOVASCULAR SYSTEM +

CHAPTER 15. DRUGS AFFECTING THE DIGESTIVE SYSTEM +

CHAPTER 16. DIURETICS +

CHAPTER 17. DRUGS AFFECTING MYOMETRIUM

CHAPTER 18. DRUGS AFFECTING HEMOPOIESIS +

CHAPTER 19. DRUGS THAT AFFECT PLATELET AGGREGATION, BLOOD COAGULATION AND FIBRINOLYSIS +

E. DRUGS THAT CONTROL METABOLIC PROCESSES

CHAPTER 20. HORMONAL DRUGS +

CHAPTER 21. VITAMINS +

CHAPTER 22. ANTIATHEROSCLEROTIC DRUGS (DRUGS USED FOR THE TREATMENT OF HYPERLIPOPROTEINEMIA)

CHAPTER 23. DRUGS USED FOR THE TREATMENT OF OBESITY

CHAPTER 24. DRUGS USED FOR THE TREATMENT AND PREVENTION OF OSTEOPOROSIS

CHAPTER 25. DRUGS USED FOR THE TREATMENT OF GOUT

CHAPTER 26. ANTI-INFLAMMATORY DRUGS

CHAPTER 27. DRUGS AFFECTING THE IMMUNE SYSTEM +

F. ANTIMICROBIAL AND ANTIPARASITIC DRUGS

CHAPTER 28. ANTISEPTICS AND DISINFECTANTS

CHAPTER 29. ANTIBACTERIAL CHEMOTHERAPEUTIC DRUGS 1 +

CHAPTER 30. ANTIVIRAL DRUGS

CHAPTER 31. ANTIFUNGAL AGENTS

CHAPTER 32. ANTIPROTOZOAL DRUGS +

CHAPTER 33. ANTIHELMINTHIC DRUGS +

CHAPTER 34. ANTINEOPLASTIC (ANTIBLASTOMIC) DRUGS +

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CHAPTER 8. PAIN-RELIEVING DRUGS (ANALGESICS)+