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Часть XX. Заболевания крови

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    lasssst bTCont-bkt1bTCont-bkt1Cont-bkt1lasssst-row-docrow-docw-doc"bTCont-ISBN9785970469217-0016Cont-ISBN9785970469217-0016t-ISBN9785970469217-0016ISBN9785970469217-0016BN9785970469217-0016reff="https://prior.studentlibrary.ru/en/doc/ISBN9785970469217-0016.html://prior.studentlibrary.ru/en/doc/ISBN9785970469217-0016.html/prior.studentlibrary.ru/en/doc/ISBN9785970469217-0016.htmlrior.studentlibrary.ru/en/doc/ISBN9785970469217-0016.htmlt-row-doc-arow-doc-aw-doc-aдисловие к изданию на русском языкеисловие к изданию на русском языкесловие к изданию на русском языкеанию на русском языкению на русском языкеию на русском языкею на русском языке на русском языкеа русском языке русском языкеусском языкесском языкеском языкеом языкем языкеыкекееivвторыторыорыы classassont-ISBN9785970469217-0020t-ISBN9785970469217-0020ISBN9785970469217-0020BN9785970469217-00209785970469217-002085970469217-0020469217-00209217-002017-0020SBN9785970469217-0020.htmlN9785970469217-0020.html785970469217-0020.html469217-0020.html9217-0020.html17-0020.htmlclassasssкторы и переводчики издания на русском языкеторы и переводчики издания на русском языкеоры и переводчики издания на русском языкеры и переводчики издания на русском языкеы и переводчики издания на русском языке и переводчики издания на русском языкеи переводчики издания на русском языкеереводчики издания на русском языкереводчики издания на русском языкееводчики издания на русском языкеодчики издания на русском языкедчики издания на русском языкеки издания на русском языкеи издания на русском языке издания на русском языке на русском языкена русском языкеа русском языкерусском языкеусском языкесском языке+
    Глава 3. Адаптивный иммунитет-
    3.1. Молекулы, распознающие антигены
    3.1.1. Иммуноглобулины/антитела
    3.1.1.1. Строение иммуноглобулинов. Полипептидные цепи
    3.1.1.2. V-домены и антигенсвязывающие участки иммуноглобулинов
    3.1.1.3. С-домены, изотипы и антигенные варианты иммуноглобулинов
    3.1.2. В-клеточный рецептор
    3.1.2.1. Мембранный иммуноглобулин
    3.1.2.2. Дополнительные полипептидные цепи В-клеточного рецептора
    3.1.3. Т-клеточный рецептор и связанные с ним молекулы
    3.1.3.1. Димеры αβ и γδ
    3.1.3.2. Комплекс CD3
    3.1.3.3. Корецепторы Т-клеток
    3.1.4. Генетические основы формирования и перестройки генов антигенраспознающих рецепторов
    3.1.4.1. Формирование генов рецепторов лимфоцитов
    3.1.4.2. Соматический мутагенез V-генов иммуноглобулинов
    3.1.4.3. Переключение константных генов иммуноглобулинов
    3.1.4.4. Переключение синтеза с мембранных на секретируемые иммуноглобулины
    3.2. Антигены
    3.2.1. Антигены, распознаваемые В-клетками, и их взаимодействие с антителами
    3.2.1.1. Чужеродность антигенов
    3.2.1.2. Иммуногенность антигенов
    3.2.1.3. Специфичность антигенов
    3.2.1.4. Взаимодействие антигенов и антител
    3.2.2. Главный комплекс гистосовместимости и антигены, распознаваемые Т-клетками
    3.2.2.1. Главный комплекс гистосовместимости
    3.2.2.2. Процессинг антигена для Т-клеток
    3.2.2.3. Особенности распознавания антигенных лигандов рецепторными комплексами Т-клеток
    3.2.2.4. Суперантигены
    3.3. Лимфоидные клетки
    3.3.1. В-лимфоциты
    3.3.1.1. Характеристика В-лимфоцитов
    3.3.1.2. Развитие В-лимфоцитов
    3.3.1.3. Субпопуляции В-лимфоцитов
    3.3.2. Т-лимфоциты
    3.3.2.1. Субпопуляции Т-клеток
    3.3.2.2. «Классические» αβТ-клетки
    3.3.2.3. Развитие αβТ-лимфоцитов
    3.3.2.4. Селекция тимоцитов и формирование субпопуляций CD4+- и CD8+-клеток
    3.3.2.5. Естественные регуляторные Т-клетки
    3.3.2.6. NKT-клетки
    3.3.2.7. γδТ-клетки
    3.4. Органы иммунной системы
    3.4.1. Первичные лимфоидные органы
    3.4.1.1. Костный мозг
    3.4.1.2. Тимус
    3.4.1.3. Бурса Фабриция. Аналоги бурсы и тимуса
    3.4.1.4. Гуморальные факторы, контролирующие развитие лимфоцитов
    3.4.1.5. Апоптоз, его роль в развитии и функционировании клеток иммунной системы
    3.4.2. Вторичные (периферические) лимфоидные органы
    3.4.2.1. Лимфатические узлы
    3.4.2.2. Селезенка
    3.4.2.3. Лимфоидная ткань слизистых оболочек
    3.4.2.4. Лимфоидная ткань, связанная с кожей
    3.4.2.5. Рециркуляция лимфоцитов
    3.4.2.6. Обновление и гомеостаз лимфоидной популяции
    3.5. Активация лимфоцитов и запуск иммунного ответа
    3.5.1. Презентация антигена
    3.5.1.1. Миграция клеток, участвующих в презентации антигена
    3.5.1.2. Иммунный синапс
    3.5.1.3. Костимуляция
    3.5.2. Активация Т-лимфоцитов
    3.5.2.1. Молекулярные основы активации Т-клеток
    3.5.2.2. Проявления активации Т-клеток
    3.5.2.3. Пролиферативная экспансия клонов Т-хелперов
    3.5.3. Дифференцировка Т-хелперов
    3.5.3.1. Th1- и Th2-клетки
    3.5.3.2. Th17 и другие адаптивные субпопуляции Т-клеток
    3.5.3.3. Цитокины, контролирующие и опосредующие адаптивные реакции лимфоцитов
    3.6. Иммунный ответ
    3.6.1. Клеточный иммунный ответ
    3.6.1.1. Цитотоксический Т-клеточный иммунный ответ
    3.6.1.2. Воспалительный Т-клеточный иммунный ответ
    3.6.2. Гуморальный иммунный ответ
    3.6.2.1. Активация В-лимфоцитов. Роль Т-клеток и цитокинов
    3.6.2.2. Дифференцировка и селекция В-клеток в зародышевых центрах
    3.6.2.3. Дифференцировка плазматических клеток и секреция антител
    3.6.2.4. Эффекторные функции антител
    3.6.2.5. Гибридомы и моноклональные антитела. Генно-инженерные антитела
    3.6.3. Иммунологическая память и вторичный иммунный ответ
    3.6.3.1. В-клетки памяти
    3.6.3.2. Т-клетки памяти
    3.6.3.3. Вторичный иммунный ответ
    3.6.4. Неклассические проявления иммунных реакций
    3.6.4.1. Функциональная активность В1-клеток
    3.6.4.2. Тимуснезависимый иммунный ответ и антигеннезависимая дифференцировка антителообразующих клеток
    3.6.4.3. Проявления активности γδТ- и CD8αα+ Т-клеток
    3.6.4.4. Иммунологические функции NKT-клеток
    3.6.5. Иммунные процессы в слизистых оболочках (мукозальный иммунный ответ)
    3.6.5.1. Роль взаимодействия микробиоты с иммунной системой хозяина в формировании мукозального иммунного ответа
    3.6.5.2. Процессы в слизистых оболочках при внедрении патогенов; врожденные лимфоидные клетки (ILC, innate lymphoid cells)
    3.6.5.3. Индуктивное и эффекторное звенья мукозального иммунного ответа
    3.6.5.4. Роль миграции клеток в мукозальном иммунитете
    3.6.5.5. Адаптивный мукозальный иммунитет
    3.6.5.6. Секреторный IgA как компонент мукозального иммунитета
    3.6.5.7. Сохранение баланса между формированием эффективного иммунного ответа и поддержанием гомеостаза
    3.6.5.8. Роль эпителиальных клеток в защите слизистых оболочек от патогенов
    3.6.5.9. Развитие мукозального иммунного ответа при повторном контакте с патогеном
    3.6.6. Контроль и регуляция иммунного ответа
    3.6.6.1. Генетический контроль иммунного ответа
    3.6.6.2. Эндокринный и нервный контроль иммунного ответа
    3.6.6.3. Регуляция иммунного ответа
    3.6.6.4. Регуляторные Т-клетки

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