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Part 1. General Microbiology, Immunology

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" class="bTCont-row-sect-a bdepth-a4">Question 3. Primary immunodeficiencies: T-cell deficiencies

Question 4. Primary immunodeficiencies: combined B-cell and T-cell deficiencies

Question 5. Primary immunodeficiencies: disorders of the complement system (complement deficiencies)

Question 6. Primary immunodeficiencies: phagocyte deficiencies

Question 7. Secondary (acquired) immunodeficiency: causes, characteristics, classification

Question 8. Clinical manifestations of immunodeficiency states

Lecture 6. Evaluation of the immune status

Question 1. Laboratory diagnosis of immunodeficiencies in children and adults: methods, assessment criteria, interpretation

Question 2. Methods of assessing the immune status

Question 3. The levels of evaluation of the immune status

Question 4. First-stage tests (tentative)

Question 5. The second-stage tests (analytical) in the evaluation of the immune status

Question 6. General rules of immunogram evaluation

Lecture 7. Serological tests: agglutination, precipitation test, complement fixation test, tests using labeled antibodies and antigens (ELISA, IFT, RIA)

Question 1. Serological tests: definition, classification and practical use

Question 2. Agglutination test: definition, mechanism, classification and practical use

Question 3. Direct agglutination tests: mechanism and practical use

Question 4. Indirect (passive) agglutination tests: mechanism and practical use

Question 5. Precipitation reaction: identification, mechanism, types, practical use

Question 6. Complement fixation test (CFT): the purpose of its carrying out, components, mechanisms

Question 7. Labelling methods for detection antigen-antibody binding

Question 8. Immunofluorescent test

Question 9. Enzyme-linked immunosorbent assay

Question 10. Radioimmunoassay (RIA)

Question 11. Western blotting (immunoblotting)

Lecture 8. Specific prevention and treatment of infectious diseases. Therapeutic, prophylactic, and diagnostic immunological preparations

Question 1. Immunoprophylaxis, immunotherapy: definitions

Question 2. The history of immunisation

Question 3. Vaccines — classification, characteristics

Question 4. Complications after vaccines, contraindications to immunisation. scheme of vaccine use

Question 5. The immunological antibody-based drugs. Classification. Characteristic (passive immunisation)

Question 6. Rules of vaccines and serums injection. Routes of vaccine injection

Lecture 9. Antiviral and antibacterial immunity. immunity in transplantation, cancer and immunity in mycoses. Immunity and age

Question 1. Features of local immunity — skin and mucous membranes

Question 2. Antibacterial and antitoxic immunity. Factors of antibacterial immunity

Question 3. Antiviral immunity

Question 4. Antifungal immunity

Question 5. Immunity in protozoa and parasitic infections

Question 6. Immunity in transplantation

Question 7. Antitumor immunity

Question 8. Immunity in pregnancy

Question 9. Age features of immunity

Test for unit 2

Раrt 2. Special Microbiology, Mycology and Virology +

Key answers for Test

List of literature

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Иерархии доказательности

Инструменты для оценки доказательств

Обобщение достижений доказательной медицины: клинические рекомендации

Проблемы применения доказательной медицины в хирургии

Анализ рандомизированного контролируемого исследования в хирургии

Внутренняя валидность

Внешняя валидность

Дополнительные проблемы при проведении рандомизированных клинических исследований в хирургии

Использование и злоупотребление статистической значимостью

Ошибки типа I и типа II

Величина P

Альтернатива величины Р